1930s replica streetcar was made for the movie by Dean Jeffries

 Jessica Rabbit drives a ’39 Packard 120, 

Bob Hoskins’ character drives a 41 Plymouth

it was the last movie Betty Boop was in with her original voice actress, it was the last movie for Mel Blanc also

This movie is the only time cartoon characters from Walt Disney and Warner Bros. have appeared together on-screen.

Since the movie was being made by Disney’s Touchstone Pictures, Warner Bros. would only allow use of their biggest cartoon stars, Bugs Bunny and Daffy Duck, if they got as much screen time as Mickey Mouse and Donald Duck. For that reason, they were always in pairs, such as the piano battle between Daffy and Donald and the parachute scene with Bugs and Mickey. This was continued with Porky Pig and Tinkerbell at the movie’s ending.

Tim Curry auditioned for the role of Judge Doom. His performance was too scary

Bill Murray was offered the role Bob Hoskins played. Since his trademark voicemail system for getting contacted for work, instead of an agent, or real phone number, was delayed in his hearing the offer, the role went to Bob Hoskins. Eddie Murphy turned down the role

Several voice actors make cameos as the voice of the character(s) they have played before. 

These are Tony Anselmo (Donald Duck), 

Wayne Allwine (Mickey Mouse), 

and Mel Blanc (Bugs Bunny, Daffy Duck, Porky Pig, Sylvester, and Tweety Bird).